Richa Singh
Pt BD Sharma Post Graduate Institute of Medical Sciences,India
Title: Correlation of spot urinary protein: creatinine ratio and quantitative proteinuria in patients of nephrotic syndrome in pediatric age group
Biography
Biography: Richa Singh
Abstract
Nephrotic Syndrome is a common disease in pediatric age group with multiple relapse. Twenty-four hour (24 hour) urinary protein excretion is the accepted method used in quantification of proteinuria, but it's a time consuming, inconvenient and cumbersome method. Spot urine examination would be more simple, easy, acceptable, and less timeconsuming method for detection of proteinuria in children.
Aim of our study is to evaluate the utility of protein: creatinine ratio in random urine sample as a reliable diagnostic tool to rule in or rule out proteinuria and to find the correlation of protein: creatinine ratio with 24 hour protein excretion which is the gold standard reference method.
The study was done on 40 pediatric patients admitted as nephrotic syndrome, either presenting for the first time or relapse case. Nephrotic syndrome was diagnosed on the basis of massive proteinuria (>40 mg/m2/hr), hypoalbuminemia and generalized edema.
The results indicated that the correlation between spot protein and creatinine ratio and 24 hour proteinuria is statistically significant with r=0.833 (p<0.01) by Pearson's correlation coefficient.
Spot protein creatinine ratio can be used as reliable test for detection of proteinuria in pediatric age group in patients of nephrotic syndrome.